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Related Experiment Video

Updated: Jul 4, 2026

Three-dimensional Optical-resolution Photoacoustic Microscopy
08:31

Three-dimensional Optical-resolution Photoacoustic Microscopy

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3D Passive Cavitation Mapping (3D-PCM) with a Large-aperture Planar Array.

Chaorui Qiu, Daiwei Li, Haoming Huo

    Biorxiv : the Preprint Server for Biology
    |July 3, 2026
    PubMed
    Summary
    This summary is machine-generated.

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    A new dual-modality imaging system enhances laser lithotripsy (LL) by mapping cavitation events. This technology offers real-time feedback for urinary stone treatment, improving precision and reducing tissue damage.

    Area of Science:

    • Urology
    • Medical Imaging
    • Acoustics

    Background:

    • Urinary stone disease incidence is rising globally.
    • Laser lithotripsy (LL) is a minimally invasive treatment for urinary stones.
    • Cavitation is crucial for stone fragmentation during LL, but its detection is challenging.

    Purpose of the Study:

    • To develop an improved three-dimensional passive cavitation mapping (3D-PCM) system for clinical use.
    • To overcome limitations in imaging depth, field of view (FOV), and procedural compatibility of existing 3D-PCM technologies.
    • To enable real-time feedback during LL procedures.

    Main Methods:

    • A large-FOV dual-modality imaging system combining 3D-PCM and B-mode ultrasound was developed.
    • A large-aperture planar ultrasound array was optimized.

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    Last Updated: Jul 4, 2026

    Three-dimensional Optical-resolution Photoacoustic Microscopy
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  • Model-based reconstruction techniques were employed to enhance FOV and resolution.
  • In vivo experiments were conducted using a porcine model.

    • Main Results:

    • The system achieved an expanded FOV of approximately 40 x 40 mm² at a depth of 110 mm.
    • High spatial resolution was maintained (0.6 mm lateral, 0.4 mm axial).
    • Reconstructed cavitation distribution correlated well with observed stone damage in the porcine model.

    Conclusions:

    • The developed dual-modality imaging system significantly expands FOV and maintains resolution for 3D-PCM.
    • This technology shows potential for real-time treatment feedback during laser lithotripsy.
    • It could improve LL efficacy and patient outcomes by visualizing cavitation events accurately.