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WWOX contributes to DNA damage, but not somatic instability in Huntington's disease

Tiziana Petrozziello, Zachariah L McLean, Adel Boudi

    Biorxiv : the Preprint Server for Biology
    |July 3, 2026
    PubMed
    Summary

    Huntington's disease (HD) involves DNA damage, but the ATM pathway is not involved. Instead, WW domain-containing oxidoreductase (WWOX) increases DNA damage in HD, independent of ATM signaling.

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