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Updated: Jul 4, 2026

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Mechanochemical synthesis of Ag nanoparticles using ascorbic acid.

Ľudmila Balážová1, Adrian Augustyniak2,3, Nina Daneu4

  • 1Department of Pharmaceutical Technology, Pharmacognosy and Botany, The University of Veterinary Medicine and Pharmacy Komenského 73 041 81 Košice Slovakia.

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|July 3, 2026
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Mechanochemical synthesis efficiently produced silver nanoparticles using ascorbic acid in 30 minutes. These potent silver nanoparticles demonstrated significant antibacterial activity against E. coli and S. aureus.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemistry

Background:

  • Silver nanoparticles (AgNPs) possess significant antimicrobial properties.
  • Developing efficient and scalable synthesis methods for AgNPs is crucial for various applications.
  • Mechanochemical synthesis offers a solvent-free and rapid approach for nanomaterial production.

Purpose of the Study:

  • To synthesize silver nanoparticles using a mechanochemical approach.
  • To characterize the synthesized silver nanoparticles.
  • To evaluate the antibacterial efficacy of the synthesized silver nanoparticles.

Main Methods:

  • Mechanochemical synthesis via planetary ball milling for 30 minutes.
  • Ascorbic acid was employed as the reducing agent.

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  • Characterization using X-ray diffraction (XRD) and FT-infrared spectroscopy (FTIR).
  • Transmission Electron Microscopy (TEM) was used for size and morphology analysis.
  • Main Results:

    • Successful synthesis of silver nanoparticles confirmed by XRD and FTIR.
    • Estimated average crystallite size of Ag nanoparticles was 54 ± 2 nm.
    • TEM analysis indicated a polymodal distribution of crystallite sizes.
    • The synthesized Ag nanoparticles exhibited potent antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus).

    Conclusions:

    • Mechanochemical synthesis is an effective method for producing silver nanoparticles.
    • The synthesized Ag nanoparticles possess significant antibacterial properties.
    • This method offers a rapid and potentially scalable route for AgNP production with antimicrobial applications.