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Related Concept Videos

Human Virome01:26

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...

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Mapping Mammalian 3D Genome Interactions with Micro-C-XL
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Mapping the multigenomic human system: structural asymmetry and interface gaps in host-exogenous biological

João Francisco Pollo Gaspary1, Luis Felipe Dias Lopes2, Fernanda Peron Gaspary3

  • 1Institute AuBento-Center for Education, Clinical Practice, and Research in Orthomolecular and Integrative Medicine, Santa Maria, Brazil.

Frontiers in Microbiology
|July 3, 2026
PubMed
Summary

This study reveals that while host-microbe functional links are well-established, the regulatory interfaces integrating these signals are under-researched. Understanding these interfaces is key to viewing the human body as a symbiotic multigenomic system.

Keywords:
membrane-level signal integrationmultigenomic human systemmultigenomic systemssystems microbiologysystems physiology

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Area of Science:

  • Host-microbiome interactions
  • Systems biology
  • Human physiology

Background:

  • Host-microbiome research has linked microbial communities to key physiological processes like immunity and metabolism.
  • However, the integration of microbial signals into human physiological regulation and the underlying organizational architecture remain unclear.
  • Regulatory interfaces connecting microbial ecology to host responses are insufficiently explored.

Purpose of the Study:

  • To systematically synthesize host-exogenous biological interactions.
  • To map evidence distribution across biological integration levels.
  • To evaluate the literature for a coherent multigenomic framework of human physiology.

Main Methods:

  • A prospectively registered systematic synthesis using a Work Breakdown Structure (WBS).
  • Literature searches categorized into functional coupling, regulatory-interface mediation, and genetic interaction.
  • Analysis involved structural mapping, cross-domain convergence, and plausibility assessment of 168 studies.

Main Results:

  • Functional host-microbe coupling is well-documented across immune, metabolic, barrier, and neuroendocrine systems.
  • Regulatory interfaces, especially membrane-associated signaling and microenvironment dynamics, are under-integrated in current literature.
  • Stabilization processes like barrier remodeling and immune recalibration converge at membrane-associated signaling platforms.

Conclusions:

  • The human organism can be viewed as a symbiotic multigenomic system integrating signals from multiple genomic sources.
  • Membrane-associated signaling interfaces act as critical regulatory nodes integrating ecological, host, and microenvironmental factors.
  • A multigenomic systems perspective offers a framework for understanding persistent regulatory configurations in human physiology.