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Structural and Functional Disruption of Thiopurine S‑Methyltransferase by the A80P Variant: A Simulation and

Kaishiv Joshi1, Rahul Kumar2, Rakesh Kumar3

  • 1Department of Human Genetics, Punjabi University, Patiala 147002, India.

ACS Omega
|July 3, 2026
PubMed
Summary

The TPMT2 (A80P) genetic variant impairs thiopurine drug metabolism by affecting enzyme structure and cofactor binding. This variant was not found in northern Indian acute myeloid leukemia patients, highlighting the need for population-specific pharmacogenetic screening.

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