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Related Experiment Video

Updated: Jul 4, 2026

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
12:27

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt

Published on: May 7, 2015

Propensity Score-matched Real-world Data: HCC Recurrence Rates After DBD Liver Transplantation in Times of Machine

Dominik Thomas Koch1, Lucca Pollety1, Malte Schirren1

  • 1Department of General, Visceral and Transplantation Surgery, LMU University Hospital, LMU Munich, Munich, Germany.

Transplantation Direct
|July 3, 2026
PubMed
Summary

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Hypothermic oxygenated machine perfusion (HOPE) may reduce early hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT). While not statistically significant in all measures, HOPE shows promise for improving oncological outcomes in HCC patients undergoing LT.

Area of Science:

  • Hepatobiliary Surgery
  • Transplantation Immunology
  • Oncology

Background:

  • Liver transplantation (LT) is a primary treatment for hepatocellular carcinoma (HCC), with recurrence rates around 15%.
  • Organ preservation techniques like hypothermic oxygenated machine perfusion (HOPE) aim to reduce ischemia-reperfusion injury (IRI).
  • The impact of HOPE on HCC recurrence post-LT requires further investigation.

Purpose of the Study:

  • To compare oncological outcomes in HCC patients undergoing LT with and without HOPE.
  • To evaluate if HOPE mitigates IRI and affects HCC recurrence rates.
  • To assess the efficacy of HOPE in improving survival post-liver transplantation for HCC.

Main Methods:

  • A retrospective cohort study of 137 patients undergoing LT for HCC using donation after brain death grafts.

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Last Updated: Jul 4, 2026

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
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Published on: May 7, 2015

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  • Cox regression analysis to identify HCC recurrence risk factors.
  • Propensity score matching to adjust for baseline differences and evaluate HOPE's impact.

    • Main Results:

    • Milan Criteria status was a significant predictor of HCC recurrence.
    • No HCC recurrence was observed in the 32 patients treated with HOPE.
    • The control group (105 patients) had an 7.6% recurrence rate within 2 years; time-to-recurrence was significantly different after matching.

    Conclusions:

    • HOPE treatment for liver grafts may decrease early HCC recurrence after LT.
    • While recurrence-free and overall survival did not significantly differ within 2 years, trends suggest HOPE's potential.
    • Further research, including RCTs and basic science studies, is needed to confirm HOPE's role in mitigating IRI and improving oncological outcomes.