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Intracardiac Thrombi in Behçet's Disease: Systematic Review of 218 Patients' Clinical Characteristics and Treatments

Anas M Barabrah1, Anas R Tuqan1, Sara M Darawish1

  • 1Department of Medicine, Al-Quds University Jerusalem, Palestine.

European Cardiology
|July 3, 2026
PubMed

Insights

Intracardiac thrombosis (ICT) in Behçet's disease (BD) often presents initially and is best treated with corticosteroids, immunosuppressants, and anticoagulants. Surgical intervention for ICT in BD is linked to higher mortality and recurrence rates.

Area of Science:

  • Cardiology
  • Rheumatology
  • Autoimmune Diseases

Background:

  • Behçet's disease (BD) is a rare autoimmune disorder.
  • Cardiovascular complications, including intracardiac thrombosis (ICT), are significant in BD.
  • ICT in BD is associated with high morbidity and mortality.

Purpose of the Study:

  • To analyze the characteristics and outcomes of intracardiac thrombosis (ICT) in Behçet's disease (BD).
  • To evaluate treatment strategies and their effectiveness for ICT in BD patients.

Main Methods:

  • Comprehensive literature search up to December 2024.
  • Analysis of 218 case reports and cohort studies on BD and ICT.
  • Extraction of data on demographics, clinical presentation, and treatment outcomes.

Main Results:

  • ICT in BD predominantly affects young males, often as an initial manifestation (53.21%).
  • Common symptoms include fever, dyspnea, and hemoptysis, with right heart chambers most affected.
  • Medical therapy (corticosteroids, immunosuppressants, anticoagulants) achieved 67.22% resolution; surgery had high recurrence (60%) and mortality (34.78%).

Conclusions:

  • ICT is a serious complication of BD requiring prompt recognition and management.
  • A multimodal medical treatment approach is recommended for better outcomes.
  • Surgical intervention for ICT in BD is associated with increased risks and should be approached cautiously.
Abstract

Keywords:
Behçet’s diseaseIntracardiac thrombosisautoimmune thrombosiscardiac involvementvascular complications

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