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Physical Activity and Sedentary Behaviour in Children With Haemophilia
Melanie Bladen1,2, Lucy Alderson1, Eleanor Main2
1Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Summary
Most boys with haemophilia (BwH) do not meet physical activity (PA) guidelines. Activity declines with age, highlighting the need for early interventions to promote lifelong health.
Area of Science:
- Pediatrics
- Sports Medicine
- Hematology
Background:
- Physical activity (PA) is crucial for child development, yet inactivity is a major global health concern.
- Boys with haemophilia (BwH) have improved therapeutic options for PA, but UK data on objectively measured activity and sedentary behavior (SB) across disease severities are scarce.
Purpose of the Study:
- To objectively measure PA and SB in BwH.
- To evaluate adherence to World Health Organization (WHO) moderate-to-vigorous physical activity (MVPA) guidelines.
Main Methods:
- Prospective cohort study of 36 boys (6-16 years) with haemophilia at a UK centre.
- 7-day accelerometer monitoring (ActiGraph GT3X) with data requiring ≥ 9 h/day for ≥ 4 days.
- Analysis of MVPA and SB using Evenson thresholds and mixed-effects models to identify correlates and odds of meeting guidelines.
Main Results:
- Median daily MVPA was 52.5 min/day, with no significant differences by disease severity.
- Age was a significant predictor: each year increased SB by 27.6 min and decreased MVPA by 7.6 min (p < 0.01).
- Only 39.8% of days met WHO MVPA guidelines, with adherence dropping from 79% at age 6 to 8% at age 14.
Conclusions:
- The majority of BwH do not meet WHO MVPA guidelines, although activity levels show promise.
- Age-related decreases in MVPA and increases in SB in BwH parallel those in the general population.
- Early, tailored interventions are essential to foster sustained physical activity throughout life for individuals with haemophilia.
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