Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Detection of perivascular spaces at the gray-white matter interface using heavily T<sub>2</sub>-weighted MRI at 7T.

NeuroImage·2026
Same author

Post-Critical Period Transcriptional and Physiological Adaptations of Primary Sensory Cortex after Sensory Loss.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

High iron in mouse olfactory ensheathing cells at the glia limitans in the olfactory bulb underlies MRI T <sub>2</sub> * hypointensity.

Imaging neuroscience (Cambridge, Mass.)·2025
Same author

Age-dependent integration of cortical progenitors transplanted at CSF-neurogenic niche interface.

Frontiers in cell and developmental biology·2025
Same author

Direct delivery of MRI contrast through skull vessel/marrow pathways into the brain guided by microCT.

Theranostics·2025
Same author

500 MHz Inductive Birdcage RF Coil for Brain MRI: Design, Implementation and Validation.

IEEE transactions on bio-medical engineering·2025

Related Experiment Video

Updated: Jul 4, 2026

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol
10:14

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

Published on: May 12, 2019

7T 3D-EPI PCASL With High SNR Efficiency and Robustness to Through-Plane B0 Field Gradients.

Gael Saib1, Alan P Koretsky1, S Lalith Talagala2

  • 1Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

Magnetic Resonance in Medicine
|July 3, 2026
PubMed
Summary
This summary is machine-generated.

Optimizing labeling duration to ~3 seconds and increasing gradient strength to 0.8 mT/m significantly enhances signal-to-noise ratio efficiency (SNReff) in 7T pseudo-continuous arterial spin labeling (PCASL) MRI. This approach improves robustness to magnetic field variations without subject-specific adjustments.

Keywords:
3D7TPCASLoff‐resonance gradientssignal‐to‐noise ratioultra‐high field MRI

More Related Videos

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
09:09

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

Subdural Soft Electrocorticography (ECoG) Array Implantation and Long-Term Cortical Recording in Minipigs
08:30

Subdural Soft Electrocorticography (ECoG) Array Implantation and Long-Term Cortical Recording in Minipigs

Published on: March 31, 2023

Related Experiment Videos

Last Updated: Jul 4, 2026

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol
10:14

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

Published on: May 12, 2019

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
09:09

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

Subdural Soft Electrocorticography (ECoG) Array Implantation and Long-Term Cortical Recording in Minipigs
08:30

Subdural Soft Electrocorticography (ECoG) Array Implantation and Long-Term Cortical Recording in Minipigs

Published on: March 31, 2023

Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Neuroimaging
  • Physiology

Background:

  • 7T pseudo-continuous arterial spin labeling (PCASL) offers potential for enhanced perfusion imaging.
  • Challenges include signal compromise due to B1 and ΔB0 inhomogeneity and high SAR limitations.
  • Optimized background suppression (BS) pulses and 3D-EPI are crucial for improving PCASL performance at 7T.

Purpose of the Study:

  • To optimize labeling duration (LD) and background suppression (BS) for 7T PCASL using 3D-EPI.
  • To quantify the impact of LD and magnetic field inhomogeneity on PCASL signal-to-noise ratio efficiency (SNReff).
  • To investigate the robustness of PCASL to ΔB0 gradients and assess the efficacy of varying mean gradients (Gmean).

Main Methods:

  • Quantified 7T PCASL SNReff across a range of LD (500-4000 ms) with optimized WURST BS pulses and 3D-EPI.
  • Investigated PCASL sensitivity to ΔB0 by measuring field variations and acquiring data with varying Gmean (-0.8 to +0.8 mT/m).
  • Implemented in-plane ΔB0 corrections during data acquisition.

Main Results:

  • Optimized WURST BS pulses achieved approximately 0.93 inversion efficiency.
  • Maximum PCASL SNReff was achieved with an LD of ~3 seconds, yielding ~25% higher SNReff compared to 1s LD.
  • Increasing Gmean from 0.4 to 0.8 mT/m increased perfusion signal by ~128% in cases with strong negative through-plane ΔB0 gradients.

Conclusions:

  • A ~3s LD with 3D-EPI and optimized WURST BS pulses maximizes 7T PCASL SNReff.
  • A Gmean of 0.8 mT/m enhances PCASL robustness to feeding artery ΔB0 gradients without subject-specific corrections.
  • Higher Gmean is beneficial for handling multiple ΔB0 polarities and non-linear field variations.