Oxygen-ozone action on Isaac's syndrome: a case report

Area of Science:

• Neurology
• Immunology
• Alternative Medicine

Background:

• Isaac's syndrome (neuromyotonia) is a rare autoimmune neuromuscular disorder causing continuous muscle fiber activity.
• Symptoms include muscle stiffness, cramps, fasciculations, and delayed relaxation, often linked to autoantibodies against voltage-gated potassium channels.
• Standard treatments like immunosuppressants offer incomplete or transient relief.

Purpose of the Study:

• To evaluate the efficacy of oxygen-ozone therapy in a patient with refractory Isaac's syndrome.
• To assess the long-term impact of this non-pharmacological approach on clinical and functional outcomes.

Main Methods:

• A case report of a 43-year-old woman with long-standing Isaac's syndrome and poor response to conventional therapies.
• Treatment involved major autohemotherapy with an oxygen-ozone (O₂-O₃) protocol.
• Clinical and electrophysiological improvements were monitored, along with functional abilities using the Barthel Index.

Main Results:

• Significant clinical and electrophysiological improvements, including resolution of neuromyotonia, were observed within two months.
• Sustained functional gains and pain control were maintained over a three-year follow-up period.
• The patient's MTHFR polymorphisms may have influenced disease presentation and treatment response.

Conclusions:

• Oxygen-ozone therapy presents a potential complementary, non-pharmacological option for refractory autoimmune neuromuscular disorders.
• Sustained benefits suggest ozone therapy may modulate the immune system, improve redox balance, and restore mitochondrial function.
• Further research is needed to establish personalized ozone-based protocols for immune-mediated neuromuscular conditions.