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Updated: Jul 4, 2026

Autologous Endothelial Progenitor Cell-Seeding Technology and Biocompatibility Testing For Cardiovascular Devices in Large Animal Model
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Bioinspired Passive Flow Routing to Mitigate Thrombosis in Prosthetic Heart Valves and Cardiovascular Devices.

Yevgeniy Kreinin1, Mark Epshtein1,2, Yahel Talmon1

  • 1Department of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|July 3, 2026
PubMed
Summary

This study introduces a bioinspired design for cardiovascular devices to reduce blood clot formation by improving blood flow and minimizing stagnant areas. This novel approach enhances device safety without needing anticoagulation therapy.

Keywords:
biomimetic designcardiovascular devicescomputational fluid dynamicshemodynamicsmedical device engineeringpassive flow modulationthrombosis

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Area of Science:

  • Biomimetics and Bioengineering
  • Cardiovascular Medicine
  • Hemodynamics

Background:

  • Device-associated thrombosis is a major complication in cardiovascular medicine.
  • Current treatments like anticoagulation therapy carry significant bleeding risks.
  • Stagnation in blood flow is a primary driver of clot formation in cardiovascular devices.

Purpose of the Study:

  • To present a bioinspired passive flow routing strategy to mitigate device-associated thrombosis.
  • To reduce blood flow stagnation and associated clot formation in cardiovascular devices.
  • To investigate the hemodynamic effects and antithrombotic potential of the novel design.

Main Methods:

  • Bioinspired design integrating circumferential routing channels into mechanical heart valve housings.
  • Computational fluid dynamics (CFD) for optimizing flow routing and analyzing shear stress.
  • In vitro fibrin clot deposition assay to assess antithrombotic properties.
  • In vivo ovine bypass model to evaluate device performance and thrombus formation without anticoagulation.

Main Results:

  • Computational optimization eliminated near-zero-shear pockets and significantly reduced low-shear exposure.
  • The routed design showed reduced peri-ring clot accumulation in vitro.
  • In vivo, the routed valve demonstrated improved sinus washout and no macroscopic thrombus formation at the sewing-ring interface after three months without anticoagulation.
  • Preliminary studies suggest applicability to other cardiovascular geometries.

Conclusions:

  • Bioinspired passive flow routing is an effective hemodynamic design strategy to mitigate thrombosis in cardiovascular devices.
  • This approach targets the root cause of stasis, offering a potential alternative to lifelong anticoagulation.
  • The findings pave the way for safer cardiovascular device development by enhancing hemocompatibility.