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Related Experiment Video

Updated: Jul 4, 2026

Chronic Social Defeat Stress in Early Adolescent Male Mice
07:06

Chronic Social Defeat Stress in Early Adolescent Male Mice

Published on: January 24, 2025

Early life stress blunts time-of-day-specific autonomic function in adult male mice.

Megan K Rhoads1, David M Pollock1, Keri M Kemp1

  • 1Section of Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
|July 3, 2026
PubMed
Summary

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American journal of physiology. Renal physiology·2025

Early life stress (ELS) disrupts autonomic function in adult mice, affecting heart rate variability basally and during stress. This disruption is time-of-day dependent, impacting cardiovascular health.

Area of Science:

  • Cardiovascular Physiology
  • Neuroscience
  • Stress Research

Background:

  • Early life stress (ELS) is a known risk factor for cardiovascular diseases, including hypertension.
  • Autonomic nervous system (ANS) dysfunction is implicated in stress-related cardiovascular pathology.
  • Understanding ELS effects on ANS is crucial for preventing hypertension.

Purpose of the Study:

  • To investigate the impact of ELS on autonomic function in adult male mice.
  • To assess baseline and stress-induced changes in heart rate, blood pressure, and heart rate variability.
  • To determine if ELS effects are time-of-day dependent.

Main Methods:

  • Maternal separation with early weaning (MSEW) model to induce ELS in mice.
  • Measurement of heart rate (HR), blood pressure (BP), locomotor activity (LMA), and heart rate variability (HRV).
Keywords:
autonomic functioncircadian rhythmsheart rate variabilitymaternal separationspectral analysis

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  • Assessment under basal conditions and during acute cage switch stress (CSS), considering circadian rhythms.

    • Main Results:

    • MSEW mice showed reduced HRV (total power, LF power) during the inactive period and a loss of diurnal rhythm.
    • Both NR and MSEW mice exhibited similar HR, BP, and LMA responses to CSS.
    • MSEW mice displayed significantly decreased HRV (total, LF, HF power) during and after CSS.

    Conclusions:

    • ELS disrupts autonomic function in mice, both at baseline and during acute stress.
    • These autonomic disruptions are evident in heart rate variability patterns.
    • The effects of ELS on autonomic function are time-of-day dependent, influencing cardiovascular regulation.