Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A self-powered ZnMo hydrogel battery patch for synergistic electrochemical wound healing.

International journal of biological macromolecules·2026
Same author

Curiosity-Driven Exploration with Information Bottleneck Representations and Matrix-Based Mutual Information.

Entropy (Basel, Switzerland)·2026
Same author

Correction to "Conductive Microneedle Patch with Electricity-Triggered Drug Release Performance for Atopic Dermatitis Treatment".

ACS applied materials & interfaces·2026
Same author

PEDOT: PSS for Implantable and Wearable Bioelectronics: From Material Engineering and Energy Storage to Clinical Translation.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Enhanced Alkaline Water Electrolysis Using Cr-Doped NiCoP/Ni<sub>3</sub>S<sub>2</sub> Hollow Nanowires with Heterointerfaces as Bifunctional Catalysts.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Deep learning-enabled versatile shape perception for soft robots via single-ended multimode fiber.

Science advances·2026

Related Experiment Video

Updated: Jul 4, 2026

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management
08:50

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Published on: September 2, 2015

A Self-Powered Dressing Based on a Zn-Mo Galvanic Cell for Accelerated Wound Repair.

Jinna Ke1, Jiaqian Sun1, Jiadi Wu1

  • 1School of Medical Devices, Shenyang Pharmaceutical University, Shenyang, China.

Small (Weinheim an Der Bergstrasse, Germany)
|July 3, 2026
PubMed
Summary

This study introduces a new biodegradable, self-powered wound dressing that uses electrical stimulation (ES) and icariin (ICA) to accelerate tissue regeneration and improve wound healing outcomes.

Keywords:
electrical stimulationelectrospinningicariinself‑powered electroactive dressing

More Related Videos

Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device
04:04

Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device

Published on: December 27, 2024

Related Experiment Videos

Last Updated: Jul 4, 2026

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management
08:50

Fabrication and Characterization of a Conformal Skin-like Electronic System for Quantitative, Cutaneous Wound Management

Published on: September 2, 2015

Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device
04:04

Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device

Published on: December 27, 2024

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Acute wounds present a significant clinical challenge, necessitating advanced strategies for tissue regeneration.
  • Current electroactive dressings often rely on external power or non-degradable components, hindering practical application and biocompatibility.
  • Electrical stimulation (ES) shows promise for wound repair by mimicking natural bioelectric cues.

Purpose of the Study:

  • To develop a self-powered, biodegradable electroactive dressing (ES-GP/ZIM) for enhanced wound management.
  • To integrate a biodegradable galvanic cell and sustained drug release for improved healing.
  • To evaluate the efficacy of the ES-GP/ZIM dressing in promoting skin wound repair.

Main Methods:

  • Fabrication of a trilayer electrospun scaffold incorporating a biodegradable Zn─Mo galvanic cell and icariin (ICA).
  • In vitro and in vivo assessment of the ES-GP/ZIM dressing in a full-thickness skin wound model.
  • Analysis of cellular and molecular mechanisms underlying the combined effects of ES and ICA on wound healing.

Main Results:

  • The ES-GP/ZIM dressing demonstrated continuous localized electrical stimulation and sustained ICA release.
  • Significant acceleration of tissue repair was observed, with ~85% wound closure by day 7 and near-complete epithelialization by day 14.
  • Combined ES and ICA effectively modulated inflammation, fibroblast migration, collagen deposition, and neovascularization.

Conclusions:

  • The developed biodegradable and self-powered ES-GP/ZIM dressing offers a promising platform for active wound management.
  • This approach effectively promotes regenerative tissue repair through combined electrical stimulation and therapeutic agent delivery.
  • The study highlights the potential of integrated, self-powered systems in advancing wound healing therapies.