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Elevated Body Mass Index Associated With Uterine Fibroids: A Retrospective Cohort Study With Bioinformatic Validation
Jian Lin1, Lulu Zhou1, Menghuang Zhao1
1Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
The Journal of Obstetrics and Gynaecology Research
|July 3, 2026
Summary
Obesity is linked to a higher incidence of uterine fibroids. Weight management may help reduce the risk of developing these common tumors, suggesting a potential clinical benefit.
Area of Science:
- Gynecology
- Endocrinology
- Oncology
Background:
- Uterine fibroids are common benign pelvic tumors in women.
- Obesity prevalence is rising globally, impacting various health conditions.
- The link between obesity and uterine fibroid development requires further investigation.
Purpose of the Study:
- To investigate the association between obesity and uterine fibroid incidence.
- To explore potential molecular mechanisms linking obesity and uterine fibroids.
- To identify key genes involved in the development of uterine fibroids.
Main Methods:
- Retrospective analysis of clinical data from 1170 women.
- Comparison of uterine fibroid incidence across body mass index categories.
- Analysis of serum lipid profiles and gene expression datasets (Gene Expression Omnibus).
- Construction of a protein-protein interaction network to identify hub genes.
Main Results:
- Higher uterine fibroid incidence observed in overweight and obese groups.
- Significant differences in Low-Density Lipoprotein Cholesterol levels between groups.
- Identified 85 common differentially expressed genes, enriched in extracellular matrix pathways.
- Pinpointed three hub genes: TGFBI, ITGA4, and VCAN.
Conclusions:
- Weight management may reduce the risk of uterine fibroids.
- Findings suggest a potential clinical relevance for weight management strategies.
- Further studies are needed to confirm these preliminary results.
