Redefining success in assisted reproductive technologies: the Embryo-Maternal-Offspring Continuum Framework

Area of Science:

• Reproductive Medicine
• Developmental Biology
• Genetics

Background:

• Assisted reproductive technologies (ART) success is traditionally measured by pregnancy and live birth rates.
• This limited definition overlooks the complex biological factors influencing maternal and offspring health.
• ART may cause subtle molecular and epigenetic alterations affecting long-term health.

Purpose of the Study:

• To propose a new conceptual model for evaluating ART success.
• To redefine ART outcomes beyond clinical endpoints.
• To emphasize a holistic, continuum-based approach to reproductive health.

Main Methods:

• This review proposes the Embryo-Maternal-Offspring Continuum Framework.
• It integrates embryonic, maternal, and offspring health factors.
• The framework links subclinical biological changes with clinical endpoints.

Main Results:

• The proposed framework redefines ART success as a dynamic, integrated process.
• It highlights the importance of multidimensional and longitudinal outcome assessment.
• It emphasizes the interconnectedness of embryonic, maternal, and paternal contributions.

Conclusions:

• Redefining ART success beyond live birth is crucial for optimal reproductive outcomes.
• The Embryo-Maternal-Offspring Continuum Framework can improve clinical decision-making and research.
• This approach supports individualized treatments and early biomarker identification for long-term health.