Related Experiment Video
Updated: Jul 4, 2026

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
Published on: July 27, 2022
Ligilactobacillus salivarius Lbs57 Exerted Antibacterial Activity and Modulated Cecal Microbiota to Reduce Foodborne
Yifang Cui1, Xu Feng1,2, Yuxin Shao1
1Beijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, Beijing Academy of Agriculture and Forestry Sciences, Institute of Animal Husbandry and Veterinary Medicine, No. 9, Shuguang Huayuan Middle Road, Beijing, 100097, China.
Abstract:
Campylobacter jejuni (C. jejuni) remains a major global foodborne pathogen, with poultry serving as a primary reservoir. This study evaluates the probiotic potential of Ligilactobacillus salivarius Lbs57 against foodborne pathogen C. jejuni. In vitro, the L. salivarius Lbs57 cell-free supernatant (CFS) exhibited broad-spectrum, thermostable antibacterial activity, with the strongest inhibition against C. jejuni. Characterization revealed the activity was pH and protease-sensitive, and resistant to chemical detergents. Multi-omics analysis, including whole-genome sequencing and peptidomics, identified a two-peptide bacteriocin, salivaricin, as the key antimicrobial agent. In chickens, prophylaxis, continuous, and post-colonization interventions significantly reduced C. jejuni cecal colonization, with achieving a 3-log reduction. Furthermore, L. salivarius Lbs57 modulated the cecal microbiota by increasing diversity and enriching beneficial genera (e.g., Bacteroides, Faecalibacterium) while suppressing pathogens like Clostridium and Streptococcus. Overall, these findings highlight the efficacy of L. salivarius Lbs57 is a promising probiotic candidate for limiting C. jejuni and enhancing gut health in poultry.
Related Concept Videos
Microbiota Modulation by Antibiotics
Microbes in the Production of Fermented Foods
Bacterial Gastroenteritis
Biological Methods for Microbial Control
Microbiota of the Large Intestine
Probiotics

