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Factors associated with thrombotic events among young adults in India, 2021-23: A multi-centric hospital-based

Tarun Bhatnagar1, Janani Surya Ravichandran2, Jeyashree Kathiresan1

  • 1ICMR School of Public Health, ICMR National Institute of Epidemiology, Chennai, Tamil Nadu, India.

The Indian Journal of Medical Research
|July 3, 2026
PubMed

Insights

COVID-19 vaccination did not increase thrombotic events like myocardial infarction in young Indian adults. Traditional risk factors and severe COVID-19 illness were linked to these events.

Area of Science:

  • Cardiology
  • Epidemiology
  • Vaccinology

Background:

  • Myocardial infarction in young adults is linked to comorbidities and lifestyle factors.
  • The relationship between COVID-19 vaccination and thrombotic events is debated globally.
  • This study investigates COVID-19 vaccination's association with thrombotic events in Indian young adults.

Purpose of the Study:

  • To determine the association between COVID-19 vaccination, lifestyle, and medical risk factors with thrombotic events in young adults in India.
  • To assess the risk of myocardial infarction and other thrombotic events in relation to COVID-19 vaccination status.

Main Methods:

  • A multicentric matched case-control study involving 18-45-year-old hospitalised patients with thrombotic events.
  • Data collected via hospital records and telephonic interviews, with matching by admission date.
  • Conditional logistic regression used for analysis, with confounder adjustments.

Main Results:

  • Acute myocardial infarction was associated with prior thrombotic events, comorbidities, smoking, and family history.
  • No association found between COVID-19 vaccination (two or more doses) and acute myocardial infarction (aOR 0.8; CI: 0.3-2.8).
  • Any thrombotic event was linked to prior thrombotic events, comorbidities, smoking, prior COVID-19 hospitalization, and family history; no association with COVID-19 vaccination (aOR 1.0; CI: 0.5-2.0).

Conclusions:

  • Thrombotic events in young Indian adults are primarily driven by traditional risk factors and severe COVID-19 illness.
  • No increased risk of thrombotic events, including myocardial infarction, was identified with COVID-19 vaccination.
  • Emphasizes addressing modifiable cardiovascular risk factors and monitoring high-risk young adults.

Keywords:
Acute myocardial infarctionCOVID-19 vaccineDirected acyclic graphThrombotic eventsYoung adults

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