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Manufacturing Chimeric Antigen Receptor (CAR) T Cells for Adoptive Immunotherapy
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A breath of fresh AIR in novel CAR T cell design

Bin-Bin Schell1,2, Laura Solt1,2

  • 1Skaggs Graduate School of Chemical and Biological Sciences at Scripps Research, Jupiter, FL 33458, USA.

Science Immunology
|July 3, 2026
PubMed

Abstract:

Insertion of a compact motif into CARs enables activation-induced receptor shedding, thereby enhancing CAR T cell potency.

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The automobile's ignition system plays a vital role by ensuring the timely ignition of the fuel-air mixture in each cylinder. This ignition is facilitated by a spark plug, which is composed of two electrodes separated by an air gap. A spark forms across this air gap when a substantial voltage is generated between the electrodes, leading to the ignition of the fuel.
One can generate a large voltage using a car battery of 12 volts with the help of inductors. Inductors are known for opposing rapid...

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