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Absolute configurations and anti-bacterial activity of two century-old maleidrides
Rongfang Qu1, Chenyu Wu1, Wenhao Mu1
1College of Life Sciences, Shanghai Normal University, Shanghai, China.
Abstract:
Two century-old maleidrides 1 and 2 were found in the marine-derived fungus Talaromyces trachyspermus. Their structures were established by the analysis of spectroscopic data. Notably, their absolute configurations were unambiguously assigned by X-ray diffraction analysis. Interestingly, compound 1 showed antibacterial activity against Escherichia coli (IC50 = 103.6 mg/mL). This was the first report on the absolute configuration of compound 2, which has not been determined for near a century.
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