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Related Experiment Video

Updated: Jul 5, 2026

Dissection of the Endolymphatic Sac from Mice
04:34

Dissection of the Endolymphatic Sac from Mice

Published on: March 29, 2021

CSNK1A1 Mediates Inner Ear Inflammation and Endolymphatic Hydrops in a Lipopolysaccharide-Induced Mouse Model.

Wenting Deng1, Lan Lai2, Zhuangzhuang Li1

  • 1Department of Otolaryngology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|July 3, 2026
PubMed
Summary

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Inhibition of casein kinase 1α1 (CSNK1A1) reduced inner ear inflammation and damage in a mouse model of Meniere's disease. This suggests CSNK1A1 inhibition may be a potential treatment for cochleovestibular disorders.

Area of Science:

  • Otolaryngology
  • Molecular Biology
  • Immunology

Background:

  • Casein kinase 1α1 (CSNK1A1) is upregulated in the endolymphatic sac of Meniere's disease patients.
  • The precise role of CSNK1A1 in Meniere's disease pathogenesis is not fully understood.

Purpose of the Study:

  • To investigate the therapeutic potential of CSNK1A1 inhibition in a mouse model of endolymphatic hydrops (EH).
  • To evaluate the effects of CSNK1A1 inhibition on hydrops, inflammation, and audiovestibular function.

Main Methods:

  • An experimental animal study utilizing a lipopolysaccharide (LPS)-induced EH mouse model.
  • CSNK1A1 inhibition was achieved using the specific inhibitor CSNK1-IN-2.
  • Evaluations included cochlear morphology, auditory brainstem response (ABR), vestibular evoked myogenic potential (VEMP), and macrophage infiltration markers (CD45, F4/80).
Keywords:
CSNK1A1Meniere's diseaseendolymphatic hydropshair cellsinflammation

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Last Updated: Jul 5, 2026

Dissection of the Endolymphatic Sac from Mice
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Published on: March 29, 2021

Dissection of Adult Mouse Stria Vascularis for Single-Nucleus Sequencing or Immunostaining
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Published on: April 21, 2023

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07:32

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Main Results:

  • CSNK1A1 inhibition significantly improved ABR thresholds and VEMP latency in EH mice.
  • Inhibition of CSNK1A1 reduced endolymphatic hydrops severity and cochleovestibular macrophage infiltration.
  • CSNK1A1 was found to be upregulated in hair cells of mice with LPS-induced EH.

Conclusions:

  • CSNK1A1 inhibition demonstrates a protective effect against LPS-induced inner ear injury.
  • Targeting CSNK1A1 may offer a novel therapeutic strategy for inflammation-associated cochleovestibular damage.