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Predicting milling performance of pharmaceutical crystals from elastic modulus.

Soumyadeep Sen1, Tianxiang Gao2, Tianyi Xiang2

  • 1Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, United States.

International Journal of Pharmaceutics
|July 3, 2026
PubMed
Summary

Predicting pharmaceutical milling particle size is now possible using a single crystal property, the reduced elastic modulus (Er). This breakthrough enables accurate predictions for fine particle reduction, offering a new physics-based approach for drug development.

Keywords:
Contact mechanicsMillingModulusNanoindentationParticle sizePredictive model

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