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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jul 5, 2026

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
07:54

Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting

Published on: March 25, 2019

Inorganic nanoparticles for diagnostics, drug delivery and therapy for solid tumors.

Lakshmi G Peetani1, Swapna P Ganji1, Ganji P Nagaraju2

  • 1Department of Chemistry, Sasi Institute of Technology & Engineering, Tadepalligudem, Andhra Pradesh 534101, India.

Drug Discovery Today
|July 3, 2026
PubMed
Summary

Inorganic nanoparticles offer advanced solutions for solid tumor treatment, overcoming limitations of current therapies. These nanomaterials enable targeted drug delivery and combined therapies, paving the way for precision oncology.

Keywords:
drug deliveryinorganic nanoparticlesphotothermal therapysolid tumortumor microenvironment

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Area of Science:

  • Nanomedicine
  • Oncology
  • Materials Science

Background:

  • Solid tumors pose significant global mortality challenges.
  • Current cancer therapies face limitations including toxicity, lack of specificity, multidrug resistance, and tumor microenvironment (TME) heterogeneity.
  • Inorganic nanoparticles (NPs) present a multifunctional platform to address these limitations.

Purpose of the Study:

  • To review the current state of inorganic NPs for cancer therapy.
  • To emphasize NP design, surface functionalization, and TME-responsive strategies.
  • To provide a framework for advancing inorganic NP-based precision oncology.

Main Methods:

  • Comprehensive review of inorganic nanomaterials including gold, silica, iron oxide, quantum dots, copper, upconversion, and carbon-based NPs.
  • Analysis of surface functionalization techniques for targeted delivery.
  • Examination of TME-responsive activation mechanisms.

Main Results:

  • Inorganic NPs facilitate enhanced imaging, targeted drug delivery, and combined therapeutic modalities.
  • Stimulus-responsive nanoplatforms can be designed to activate specifically within the TME.
  • The TME's characteristics (hypoxia, low pH, oxidative stress) can be leveraged for targeted NP activation.

Conclusions:

  • Inorganic NPs are promising tools for overcoming challenges in solid tumor treatment.
  • TME-responsive inorganic NPs offer a pathway to enhanced efficacy and reduced side effects.
  • This review provides an integrated perspective for researchers and clinicians in precision oncology.