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Published on: March 21, 2025
Diagnosis and Staging of Patients with Prostate Cancer: Report from the 2025 Advanced Prostate Cancer Consensus
Stefano Fanti1, Fabio Turco2, Bertrand Tombal3
1Department of Nuclear Medicine, IRCCS AOU Bologna, Bologna, Italy.
European Urology
|July 3, 2026
Summary
Consensus on prostate cancer (PC) management was limited in the APCCC Diagnostics 2025 survey, with agreement reached on only 19% of questions. These results highlight areas needing further research to guide clinical practice.
Area of Science:
- Oncology
- Urology
- Medical Diagnostics
Background:
- The Advanced Prostate Cancer Consensus Conference (APCCC) addresses critical aspects of prostate cancer (PC) management.
- APCCC Diagnostics 2025 was a pilot project focused on key questions in PC diagnosis and management.
- 88 multiple-choice questions were developed by a scientific committee for panel voting.
Purpose of the Study:
- To present the voting results from the APCCC Diagnostics 2025 consensus questions.
- To identify areas of agreement and disagreement among experts regarding PC diagnostic tools and clinical management.
- To inform physicians, funders, and policymakers about current consensus levels and research priorities.
Main Methods:
- A panel of experts voted on 88 multiple-choice questions via a web-based survey.
- Consensus was defined as ≥75% agreement among panellists.
- Strong consensus was defined as ≥90% agreement.
Main Results:
- Consensus was achieved on only 17 out of 88 questions (19%).
- Strong consensus was reached on only six questions (7%).
- Specific consensus levels varied across topics, with "how to stage PC" showing the highest agreement (44%) and "monitoring metastatic PC" showing none (0%).
Conclusions:
- The voting results highlight significant controversies and a lack of consensus in several areas of PC clinical management.
- These findings can assist physicians in navigating complex diagnostic and staging decisions, especially where evidence is limited.
- The study identifies critical areas for future research funding and policy prioritization in prostate cancer diagnostics and management.
