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Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

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Related Experiment Video

Updated: Jul 5, 2026

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures
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Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Published on: November 22, 2024

Topical Insulin for Corneal Persistent Epithelial Defects: A Multicenter Retrospective Study.

Filippo Lixi1, Alessandra Mancini2, Costanza Rossi3

  • 1Eye Clinic, Department of Surgical Sciences, University of Cagliari, Cagliari, Italy.

Ophthalmology and Therapy
|July 3, 2026
PubMed
Summary

Insulin eye drops effectively treat persistent epithelial defects (PEDs) in eyes unresponsive to standard therapies. This study shows high healing rates and improved vision with minimal recurrence, offering a promising treatment option.

Keywords:
Corneal reepithelializationInsulin eye dropsPEDsPersistent corneal epithelial defects

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Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells
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Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Published on: April 7, 2016

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Last Updated: Jul 5, 2026

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures
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Published on: November 22, 2024

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells
11:13

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Published on: April 7, 2016

Area of Science:

  • Ophthalmology
  • Corneal Disease
  • Wound Healing

Background:

  • Persistent epithelial defects (PEDs) pose a significant clinical challenge, often proving refractory to conventional treatments.
  • The management of non-healing corneal wounds requires innovative therapeutic strategies.

Purpose of the Study:

  • To evaluate the clinical efficacy and safety of topical insulin eye drops for treating corneal persistent epithelial defects (PEDs) resistant to standard therapies.
  • To assess outcomes in a real-world patient cohort.

Main Methods:

  • Retrospective analysis of patients with refractory PEDs treated with topical insulin (1 IU/mL) four times daily.
  • Key endpoints included time to reepithelialization, closure probability, defect area changes, visual acuity, complications, and recurrence.

Main Results:

  • High closure rate (97.8%) achieved in 45 eyes, with a median time to healing of 29 days.
  • Significant improvement in best-corrected visual acuity (BCVA) from 2.0 to 1.0 logMAR post-epithelial closure.
  • Low recurrence rate (4.4%) and no reported treatment-related adverse events.

Conclusions:

  • Topical insulin demonstrates safety and effectiveness as a therapeutic option for refractory PEDs.
  • Achieves high reepithelialization rates, visual improvement, and low short-term recurrence.
  • Represents an accessible treatment for a heterogeneous patient population with challenging corneal conditions.