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Published on: August 30, 2019
Establishing human immune system mice: application, opportunity, and challenges.
Pei-Chuan Chiang1, Hung Lee-Chan1, Yungling Leo Lee2,3
1Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Experimental & Molecular Medicine
|July 3, 2026
Summary
Human immune system (HIS) models using immunodeficient mice accelerate drug development. These models improve disease study and therapeutic evaluation, bridging the gap in clinical trials for better outcomes.
Area of Science:
- Immunology
- Pharmacology
- Translational Medicine
Background:
- Human immune system (HIS) models are crucial for studying diseases and evaluating drug efficacy.
- Existing models face challenges in fully recapitulating human immune responses.
- There is a need for advanced HIS models to bridge the gap between preclinical research and clinical trials.
Purpose of the Study:
- To provide a comprehensive overview of immunodeficient mouse strains used for human immune cell development.
- To highlight the applications of HIS models in disease modeling and drug development.
- To discuss challenges and advancements in establishing robust HIS models.
Main Methods:
- Review of literature on immunodeficient mouse strains and HIS model development.
- Analysis of single-cell RNA sequencing applications in HIS mice.
- Summary of recent advancements and preclinical case studies.
Main Results:
- Various immunodeficient mouse strains support human immune cell development.
- Single-cell RNA sequencing is a powerful tool for target identification and mechanistic studies in HIS models.
- Recent advancements are enhancing human immune cell development in these models.
Conclusions:
- HIS mouse models are essential preclinical platforms for drug development and clinical trial support.
- These models facilitate the study of disease mechanisms and therapeutic responses.
- Continued advancements promise more functional and predictive HIS models for future research.
