Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lysosomal Hydrolases01:22

Lysosomal Hydrolases

Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Region-Specific Lipid Alterations Around the 28-Year Transition as Early Indicators of Skin Aging.

Metabolites·2026
Same author

Screening natural raw materials and product development for improving insomnia based on network pharmacology and data mining.

Medicine·2026
Same author

Blood-derived ratio indexes associated with severity and prognosis of immune checkpoint inhibitor-related cardiotoxicity: a retrospective analysis.

Frontiers in oncology·2025
Same author

Potential Transmission of Alpha-Synuclein from the Gastrointestinal Tract to the Substantia Nigra along the Vagal Afferent Pathway.

Neuroscience bulletin·2025
Same author

Dynamic Changes in Symptom Clusters and Symptom Networks in Patients With Multiple Myeloma: A Cross-lagged Network Analysis.

Cancer nursing·2025
Same author

G Protein-coupled receptors: key targets for maintaining the function of basal ganglia-thalamus-cortical circuits in Parkinson's disease.

Biochemical pharmacology·2025

Related Experiment Video

Updated: Jul 5, 2026

Revealing the Ferroptotic Phenotype of Medulloblastoma
04:01

Revealing the Ferroptotic Phenotype of Medulloblastoma

Published on: March 15, 2024

Rethinking LPCAT3 roles in human disease: broadening perspectives beyond ferroptosis.

Zihan Lin1, Qian Jiao1, Siqi Liu1

  • 1Department of Physiology, Shandong Key Laboratory of Pathogenesis and Prevention of Brain Diseases, State Key Disciplines: Physiology, School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao, China.

Cell Death & Disease
|July 3, 2026
PubMed
Summary

Lysophosphatidylcholine acyltransferase 3 (LPCAT3) integrates non-ferroptotic functions, including autophagy and inflammatory signaling. This review explores LPCAT3

Related Experiment Videos

Last Updated: Jul 5, 2026

Revealing the Ferroptotic Phenotype of Medulloblastoma
04:01

Revealing the Ferroptotic Phenotype of Medulloblastoma

Published on: March 15, 2024

Area of Science:

  • Biochemistry and Molecular Biology
  • Cellular Biology
  • Pathophysiology

Background:

  • Lysophosphatidylcholine acyltransferase 3 (LPCAT3) is recognized for its role in phospholipid remodeling and ferroptosis.
  • Emerging evidence suggests LPCAT3 possesses functions beyond ferroptosis, impacting cellular homeostasis and signaling.
  • Understanding these broader roles is crucial for comprehending LPCAT3's involvement in disease.

Purpose of the Study:

  • To provide a comprehensive overview of LPCAT3 functions extending beyond ferroptosis.
  • To review the structural, enzymatic, and regulatory characteristics of LPCAT3.
  • To elucidate LPCAT3's impact on cellular processes and its role in human diseases.

Main Methods:

  • Literature review and synthesis of existing research on LPCAT3.
  • Analysis of LPCAT3's structural and enzymatic properties.
  • Examination of downstream effects of LPCAT3-mediated phospholipid remodeling.

Main Results:

  • LPCAT3 mediates phospholipid remodeling, influencing membrane biophysical properties.
  • LPCAT3 regulates autophagy, endoplasmic reticulum homeostasis, and inflammatory signaling pathways.
  • LPCAT3 plays a significant role in the pathogenesis of various human diseases, including neurodegenerative disorders, stroke, atherosclerosis, diabetes, obesity, NAFLD, and cancer.

Conclusions:

  • LPCAT3 is a multifaceted enzyme with critical roles beyond ferroptosis.
  • LPCAT3-mediated cellular processes are implicated in a wide spectrum of human diseases.
  • Further research into LPCAT3's non-ferroptotic functions may offer novel therapeutic strategies.