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Updated: Jul 5, 2026

An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay
Published on: January 26, 2019
Preventive effectiveness of respiratory syncytial virus vaccination in older adults: a multi-institutional cohort
Chien-Ming Chao1, Ya-Wen Tsai2,3, Bin Zhang4
1Department of Intensive Care Medicine, Chi Mei Hospital, Liouying, Tainan, Taiwan.
Background:
This multi-institutional study evaluated the real-world effectiveness of respiratory syncytial virus (RSV) vaccination in preventing RSV infections among adults aged 50 and older.
Methods:
Using data from the TriNetX Research Network, we included individuals aged ≥ 50 years between January 1, 2023, and May 31, 2026. Patients were categorized into vaccinated and unvaccinated groups, defined as those receiving any RSV vaccine and any non-RSV vaccine, respectively. After 1:1 propensity score matching, we estimated hazard ratios (HR) for the composite outcome of RSV infection using Cox proportional-hazards models.
Results:
The study included 179,871 patients in each group after matching. The vaccinated group had a lower risk of RSV infection compared to the unvaccinated group (incidence rate: 0.17 vs. 0.27 per 100 person-years, HR, 0.65; 95% CI, 0.58-0.73). Additionally, the vaccinated group showed lower risks of RSV-associated lower respiratory tract disease (incidence rate: 0.12 vs. 0.19 per 100 person-years, HR, 0.69; 95% CI, 0.60-0.79). Risk reductions were consistent across subgroups defined by age, sex, and comorbidity.
Conclusions:
This large real-world study demonstrates the substantial effectiveness of RSV vaccination in preventing infections among older adults, a high-risk population.
Clinical Trial Number:
Not applicable.
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