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Liposomal drug delivery for lung cancer therapy: progress, challenges, and future perspectives

Abulfazl Vatankhah1,2, Sepehr Hoseinzadeh Moghaddam2, Mohsen Rahmanian2

  • 1Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.

Molecular Cancer
|July 4, 2026
PubMed

Insights

This review details how liposomes (lipid-based nanoparticles) are engineered for lung cancer therapy, overcoming challenges like multidrug resistance (MDR) and enhancing treatment efficacy through advanced formulations and delivery strategies.

Area of Science:

  • Nanomedicine
  • Oncology
  • Drug Delivery

Background:

  • Lung cancer is a leading cause of cancer mortality worldwide.
  • Liposomes are established nanocarriers for drug delivery, but their application in lung cancer therapy requires further definition.
  • Current liposomal formulations and design principles for lung cancer treatment are not fully elucidated.

Purpose of the Study:

  • To provide a comprehensive analysis of engineered liposomal delivery systems for lung cancer therapy.
  • To review strategies for overcoming biological and therapeutic challenges in lung cancer treatment using liposomes.
  • To offer a unified framework for liposome-based platforms in lung cancer therapy.

Main Methods:

  • Comprehensive literature review of liposomal formulations for lung cancer.
  • Analysis of liposome-based delivery of chemotherapeutics, immunotherapeutics, phytochemicals, nucleic acids, and photo-enabled modalities.
  • Examination of surface engineering, functionalization, biomimetic, stimuli-responsive, and theranostic liposome designs.

Main Results:

  • Liposomes are engineered to deliver chemotherapeutics, overcoming multidrug resistance (MDR).
  • Surface modifications enhance active targeting and therapeutic efficacy of liposomal formulations.
  • Innovative liposomal platforms include biomimetic, stimuli-responsive, and theranostic systems for advanced lung cancer treatment.
  • Pulmonary delivery of anticancer agents using liposomes is evaluated, integrating nanomedicine principles.

Conclusions:

  • Liposomal systems offer versatile platforms for diverse lung cancer therapeutic strategies.
  • Rational design principles and translational perspectives are crucial for advancing liposome-based lung cancer therapies.
  • This review consolidates mechanistic insights and design strategies for liposome applications in lung cancer.
Keywords:
ImmunotherapyLiposomal drug deliveryLung cancerMultidrug resistancePulmonary deliveryTargeted therapy

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