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Decoding the dynamic extracellular matrix in cancer-3D models and bioscaffolds rewire the rules of tumor progression
Sylvia Mangani1, Konstantinos Spanopoulos1, Zoi Piperigkou1
1Biochemistry, Biochemical Analysis and Matrix Pathobiology Res. Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26504, Greece.
Abstract:
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three-dimensional cancer models more accurately reflects in vivo conditions compared to conventional two-dimensional systems. Matrix engineering through bioscaffolds supports physiologically relevant tumor modeling, while matrix-based platforms offer valuable tools for preclinical research and therapeutic development.
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