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Related Experiment Video

Updated: Jul 5, 2026

Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment
04:00

Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment

Published on: July 26, 2024

Association Between the Modified Frailty Index and Short-Term Total Thyroidectomy Complications.

Tyler Jung1, Eman Ahmad1, Oluwatobiloba Ayo-Ajibola1

  • 1Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.

The Laryngoscope
|July 4, 2026
PubMed
Summary

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Higher Modified Frailty Index (mFI-5) scores correlate with increased postoperative complications following total thyroidectomy. This highlights the importance of frailty assessment for better surgical risk stratification and improved patient outcomes.

Area of Science:

  • Surgical oncology
  • Geriatric surgery
  • Health services research

Background:

  • The Modified Frailty Index (mFI-5) is a validated tool for preoperative risk stratification in surgery.
  • Its predictive value for outcomes after total thyroidectomy requires further evaluation.

Purpose of the Study:

  • To assess the association between the mFI-5 score and postoperative complications in patients undergoing total thyroidectomy.
  • To determine if mFI-5 can improve risk stratification for this patient population.

Main Methods:

  • Retrospective cohort study of 65,866 adult total thyroidectomy patients (2006-2025) using the TriNetX U.S. Network.
  • Patients stratified by mFI-5 scores (0, 1, 2, ≥3) based on five ICD-10 comorbidities.
  • Propensity score matching and logistic regression used to analyze associations between mFI-5 and outcomes (hypocalcemia, vocal fold paralysis, SSI, hematoma, tracheostomy, mortality, ED visits) within 30 days.
Keywords:
TriNetXfrailtyotolaryngologythyroidectomy

Related Experiment Videos

Last Updated: Jul 5, 2026

Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment
04:00

Identifying Frailty Using Point-of-Care Ultrasonography: Image Acquisition and Assessment

Published on: July 26, 2024

Main Results:

  • Postoperative complications significantly increased with higher mFI-5 scores.
  • Elevated odds of hypocalcemia, vocal fold paralysis, surgical-site infection, neck hematoma, and emergency department visits observed with increasing frailty.
  • Mortality events were rare, precluding reliable estimation.

Conclusions:

  • Higher mFI-5 scores are linked to increased postoperative complications after total thyroidectomy.
  • Integrating frailty assessment into preoperative evaluations can enhance risk stratification and potentially improve patient outcomes.