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Published on: August 28, 2015
Untreated Rosehip Powder/Poly(Lactic Acid)/Poly(3-Hydroxybutyrate-Co-4-Hydroxybutyrate) Electrospun Mats for Wound
Naciye Akman1, Sema Samatya Yilmaz2,3, Ikrime Orkan Ucar4
1Faculty of Chemistry and Metallurgy, Department of Bioengineering, Yıldız Technical University, Istanbul, Turkey.
Biopolymers
|July 4, 2026
Summary
Rosehip (RoHi) powder incorporated into poly(lactic acid)/poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (PLA/P(3HB-co-4HB)) nanofibers enhances wound healing properties. These antioxidant-rich, biocompatible nanofibrous mats show potential for chronic wound dressings.
Area of Science:
- Biomaterials Science
- Polymer Science
- Wound Healing Research
Background:
- Developing advanced wound dressings is crucial for effective tissue repair.
- Electrospun polymer blends offer versatile platforms for drug delivery and tissue engineering.
- Incorporating natural compounds can impart beneficial biological properties to biomaterials.
Purpose of the Study:
- To investigate the effects of rosehip (RoHi) powder on the properties of electrospun PLA/P(3HB-co-4HB) nanofibrous mats.
- To evaluate the structural, mechanical, wettability, and biological characteristics of RoHi-doped nanofibers.
- To assess the potential of these materials as wound dressings for chronic wounds.
Main Methods:
- Direct incorporation of untreated rosehip powder into PLA/P(3HB-co-4HB) (70/30, w/w) blends for electrospinning.
- Characterization of nanofibrous mats using FTIR, SEM (for fiber diameter), contact angle measurements, and liquid adsorption capacity analysis.
- Evaluation of biological properties including cytotoxicity (MTT assay), in vitro scratch assays for fibroblast migration, antioxidant activity (DPPH assay), and antibacterial activity testing.
Main Results:
- Rosehip addition altered fiber diameter, with preservation of RoHi functional groups in the polymer matrix.
- Increased liquid adsorption capacity and reduced water contact angle were observed with increasing RoHi content.
- All samples exhibited biocompatibility, with enhanced fibroblast migration and wound closure observed in RoHi-doped nanofibers.
- Significant increase in antioxidant activity was noted, but no antibacterial activity against tested strains was detected.
Conclusions:
- RoHi-doped PLA/P(3HB-co-4HB) nanofibers demonstrate improved wettability, liquid adsorption, and enhanced wound healing capabilities.
- The materials possess significant antioxidant properties and biocompatibility, making them suitable for wound dressing applications.
- These findings suggest promising potential for RoHi-containing nanofibers in the management of chronic wounds.
