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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
Nociception01:44

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...
Somatosensation01:33

Somatosensation

The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.

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Related Experiment Video

Updated: Jul 6, 2026

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)

Published on: January 27, 2010

Are Conditioned Pain Modulation and Pain Sensitivity Risk Factors for the Development of Functional Somatic Disorder?

Lise Kirstine Gormsen1,2, Tina Birgitte Wisbech Carstensen1,2, Sine Skovbjerg2

  • 1Department of Functional Disorders, Aarhus University Hospital, Aarhus, Denmark.

European Journal of Pain (London, England)
|July 4, 2026
PubMed
Summary
This summary is machine-generated.

Altered pain regulation, including pressure pain threshold and conditioned pain modulation, does not predict the development of functional somatic disorder (FSD) in the general population over five years. This challenges previous assumptions about FSD onset mechanisms.

Keywords:
chronic paincold pressor testconditioned pain modulationepidemiologyfunctional somatic disordergeneral populationpressure pain thresholds

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Last Updated: Jul 6, 2026

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Area of Science:

  • Neuroscience
  • Pain Research
  • Psychiatry

Background:

  • Functional somatic disorder (FSD) is often linked to disrupted pain regulation.
  • However, large-scale population-based evidence supporting this link is limited.
  • This study investigates pain regulation as a potential risk factor for FSD development.

Purpose of the Study:

  • To examine if altered pain regulation, specifically lower pressure pain threshold (PPT) and reduced conditioned pain modulation (CPM), predicts the onset of FSD.
  • To assess this risk over a 5-year period in a large Danish population cohort.

Main Methods:

  • Baseline PPT and CPM were measured in 2198 adults.
  • Participants were followed for 5 years, with incident FSD cases identified via questionnaires.
  • Logistic regression analyzed associations between pain measures and FSD development.

Main Results:

  • No significant association was found between baseline PPT or CPM and incident FSD.
  • Changes in PPT from baseline to follow-up also did not predict FSD development.
  • Odds ratios for PPT and CPM were consistently non-significant.

Conclusions:

  • Findings do not support altered pain regulation as a risk factor for FSD in the general population.
  • This contrasts with findings from clinical samples and questions the causal role of central pain mechanisms in FSD.
  • Limitations include potential outcome misclassification and measurement constraints.