Related Experiment Video
Updated: Jul 6, 2026

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health
Published on: April 28, 2022
Paradigm Shift of Microbiota-gut-brain Axis During Aging: Potential Role of Probiotics to Improve Cognitive Decline
Sneha Dutta1, Tapas K Dutta2, Pramod K Nanda3
1All India Institute of Medical Sciences, Bhubaneswar, Odisha, 751019, India.
Abstract:
Population aging is a global demographic inevitability, driven by advancements in healthcare, increased life expectancy, and declining fertility rates. Growing evidence implicates gut microbiota dysbiosis in the pathogenesis of cognitive impairments and neurodegenerative disorders commonly associated with aging, primarily through disruptions in immune, metabolic, and neuroendocrine signaling along the gut-brain axis. This review synthesizes current literature on the therapeutic potential of probiotic bacteria, such as Lactobacillus and Bifidobacterium, to enhance glial function, maintain blood-brain barrier integrity, and neurocognitive performance in older adults. However, probiotic efficacy is highly strain-specific and context-dependent, necessitating individualized evaluation of each microbial strain's therapeutic profile. Future research should prioritize precision microbiome-based strategies to elucidate mechanisms of action, optimal strain combinations, and their effectiveness across varying degrees of cognitive decline in the aging population. Furthermore, diet, physical activity, and microbial exposures represent essential, non-pharmacological tools for maintaining microbiota eubiosis and supporting neurocognitive health in aging populations.
Related Concept Videos
Gut-Brain Axis
Development of Human Microbiota
Probiotics
Microbiota Modulation by Antibiotics
Dysbiosis of the Gut Microbiota
Functions of the Gut Microbiota
