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Updated: Jul 6, 2026

Assessment of Chemical Toxicity in Adult Drosophila Melanogaster

Assessment of Chemical Toxicity in Adult Drosophila Melanogaster

Published on: March 24, 2023

Associations between diet quality and multiple chemical exposures.

Zhilu Pei¹, Dayu Hu¹, Rui Chen¹

¹Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing, China; Department of Nutrition and Food Safety, School of Public Health, Nanjing Medical University, Nanjing, China.

Ecotoxicology and Environmental Safety

|July 4, 2026

Summary

A healthier diet, measured by the Healthy Eating Index 2020 (HEI-2020), was linked to higher levels of some environmental chemicals like arsenic and mercury. Conversely, it was associated with lower levels of others, such as cadmium.

Keywords:

Diet quality Environmental chemical exposure Healthy eating index NHANES

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Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction

Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction

Published on: January 12, 2020

Area of Science:

Environmental Health
Nutritional Science
Toxicology

Background:

Diet quality significantly impacts health and can influence exposure to environmental chemicals.
Limited evidence exists on the relationship between comprehensive dietary indices and chemical exposures.
Understanding these associations is crucial for public health strategies.

Purpose of the Study:

To investigate the associations between diet quality, assessed by the Healthy Eating Index 2020 (HEI-2020), and exposure levels to multiple environmental chemicals.
To identify specific dietary components contributing to these associations.

Main Methods:

Utilized data from the National Health and Nutrition Examination Survey (NHANES) 2017-2020 for primary analysis and 2013-2020 for validation.
Employed survey-weighted regression models to analyze associations between HEI-2020 scores and chemical concentrations.
Used generalized additive models for nonlinearity exploration and component-level analyses.

Main Results:

Higher HEI-2020 scores correlated positively with urinary nitrate, urinary arsenic, and blood mercury.
Negative associations were found between higher HEI-2020 scores and blood cadmium and perfluorononanoic acid.
Vegetables, greens, seafood, plant proteins, and fruits were identified as key dietary contributors to specific chemical associations.

Conclusions:

Healthier dietary patterns may be associated with both beneficial nutrients and increased exposure to certain environmental toxicants.
Results underscore the need for integrated nutrition and environmental health strategies.
These strategies should aim to maximize dietary benefits while minimizing toxicant exposure.