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Updated: Jul 6, 2026
Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
Published on: January 22, 2018
Preclinical evaluation of novel FGFR2-targeting peptide probes for PET imaging and intraoperative navigation in
Xiaoqiang Yang1, Jing Zhao1, Kaili Xie1
1State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, Guangdong, China.
Abstract:
Fibroblast growth factor receptor 2 (FGFR2) is extensively acknowledged as a clinically significant biomarker across various cancer types, exhibiting elevated expression levels in numerous malignancies, with particularly pronounced overexpression in gastric cancer. In the present study, we refined a radioligand, [68Ga]Ga-DOTA-PF, through modification of FGFR2-targeting peptides to facilitate positron emission tomography (PET) imaging of FGFR2 expression. This radiotracer demonstrated an affinity for FGFR2 of 98.6 ± 9.27 nM, alongside superior stability and favorable pharmacokinetic characteristics. Dynamic PET imaging revealed substantial specific accumulation of [68Ga]Ga-DOTA-PF in FGFR2-positive gastric cancer tissues, allowing for rapid and precise detection of FGFR2 expression. Additionally, we engineered a highly sensitive fluorescent probe by conjugating indocyanine green, which enabled real-time intraoperative navigation of gastric cancer via accurate delineation of tumor margins in vivo. Collectively, FGFR2-targeted PET and near-infrared fluorescence (NIRF) imaging represent a promising non-invasive approach for the precise diagnosis of gastric cancer.
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