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Updated: Jul 6, 2026
11:08
A Facile Protocol to Generate Site-Specifically Acetylated Proteins in Escherichia Coli
Published on: December 9, 2017
Protein acetylation modification in tissue fibrosis: Opportunities and challenges
Jie Hu1, Xinyue Dou2, Yongyuan Xiao2
1The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, 310000, China.
Pharmacology & Therapeutics
|July 4, 2026
Summary
Protein acetylation, a key post-translational modification, plays a vital role in fibrotic pathogenesis. Understanding acetylation
Area of Science:
- Biochemistry
- Molecular Biology
- Pathology
Background:
- Protein acetylation (lysine acetylation) is a dynamic post-translational modification (PTM) regulated by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs).
- Acetylation is implicated in critical cellular processes including transcriptional regulation, DNA damage response, cytoskeletal remodeling, and autophagy.
- Fibrosis, a pathological condition of excessive extracellular matrix deposition following chronic injury, affects multiple organs (heart, liver, lungs, kidneys).
Purpose of the Study:
- To systematically review the biochemical characteristics of protein acetylation.
- To elucidate the role of protein acetylation in the pathogenesis of tissue fibrosis.
- To discuss the interplay between acetylation and other PTMs and propose therapeutic opportunities.
Main Methods:
- Systematic literature review.
- Analysis of biochemical properties of protein acetylation.
- Discussion of existing research on acetylation in fibrosis and PTM interplay.
Main Results:
- Protein acetylation is a crucial regulator in fibrotic pathogenesis across various organs.
- Emerging evidence links acetylation to key fibrotic processes.
- Interplay with other PTMs and potential therapeutic targets are identified.
Conclusions:
- Protein acetylation is a significant factor in the development and progression of organ fibrosis.
- Further research into acetylation targets, profiling techniques, and therapies holds promise for treating fibrotic diseases.
- This review highlights knowledge gaps and future research directions in the field.
Keywords:
Biochemical characteristicsPharmacologyProtein acetylationTherapeutic opportunitiesTissue fibrosisMore Related Videos
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