Related Experiment Video
Updated: Jul 7, 2026

10:04
Enhancing Tumor Content through Tumor Macrodissection
Published on: February 12, 2022
AID and MUM1 Negativity Identifies a Prognostically Favorable Subgroup of Diffuse Large B-Cell Lymphoma/High-Grade
Masashi Miyaoka1, Joaquim Carreras1, Yara Yukie Kikuti1
1Department of Pathology, School of Medicine, Tokai University, Isehara, Japan.
Pathology International
|July 5, 2026
Abstract:
Immunohistochemical negativity of AID and MUM1 identifies a prognostically favorable subgroup of diffuse large B-cell lymphoma/high-grade B-cell lymphoma with double-hit MYC and BCL2 or BCL6 and triple hit, and a gene set and enrichment analysis showed that genes belonged to PI3K-Akt, matrix remodeling and metastasis, cell adhesion and migration, myeloid compartment, and metabolic stress were up-regulated in the AID-negative/MUM1-negative subgroup.

