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Immune tolerance platforms to mitigate unwanted immune responses
Vincent Chak1, Sathy Balu-Iyer1
1Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14214, USA.
Journal of Pharmaceutical Sciences
|July 5, 2026
Summary
Tolerance-inducing strategies offer a promising approach to manage unwanted immune responses like autoimmune diseases and allergies. This review examines current platforms, their mechanisms, safety, and clinical potential for immune homeostasis restoration.
Area of Science:
- Immunology
- Translational Medicine
- Drug Development
Background:
- Unwanted immune responses cause autoimmune diseases, allergies, and anti-drug antibodies.
- Immune tolerance induction is a key strategy to restore immune homeostasis.
- Biological therapeutics face challenges from anti-drug antibody formation.
Purpose of the Study:
- To provide an overview of current tolerance-inducing platforms.
- To discuss the immunological mechanisms and safety profiles of these platforms.
- To assess the clinical translation potential of tolerance strategies.
Main Methods:
- Review of current literature on immune tolerance platforms.
- Analysis of distinct mechanisms of action and administration routes.
- Evaluation of safety profiles and clinical applicability.
Main Results:
- Multiple tolerance platforms have been developed over the past decade.
- Platforms vary in immunological mechanisms, administration, and safety.
- Significant progress has been made in understanding and applying tolerance induction.
Conclusions:
- Tolerance-inducing platforms hold great promise for treating immune-related disorders.
- Further research is needed to address challenges in rational design and clinical application.
- Optimizing safety and efficacy is crucial for successful clinical translation.
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