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Preparation of Amines: Reduction of Oximes and Nitro Compounds01:29

Preparation of Amines: Reduction of Oximes and Nitro Compounds

Oximes can be reduced to primary amines using catalytic hydrogenation, hydride reduction, or sodium metal reduction. The reduction of aliphatic and aromatic nitro compounds to primary amines takes place by either catalytic hydrogenation or by using active metals like Fe, Zn, and Sn in the presence of an acid.
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Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure to...
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Related Experiment Video

Updated: Jul 7, 2026

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects
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Published on: May 4, 2021

Reducing Nitrous Oxide Emissions Across the Melbourne Biomedical Precinct.

Ross Robertson1, Andrew Downey2, Daryl Williams3,4

  • 1Department of Anaesthesia, Perioperative Medicine and Pain Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

The Medical Journal of Australia
|July 5, 2026
PubMed
Summary

Australian hospitals are reducing nitrous oxide (N2O) emissions, a major source of greenhouse gases from anesthetic gas leaks. Strategies include decommissioning piped N2O systems and exploring alternatives, showcasing diverse approaches to environmental sustainability in healthcare.

Keywords:
anaesthesiaanaesthesia, obstetricalanaesthesia, paediatricclimate changeglobal warming

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Published on: December 20, 2016

Area of Science:

  • Environmental Science
  • Healthcare Sustainability
  • Anesthesiology

Background:

  • Nitrous oxide (N2O) is a significant contributor to greenhouse gas emissions in Australian healthcare, primarily from leaks in reticulated anesthetic gas systems.
  • Recent Australasian guidelines no longer mandate the use of a reticulated N2O supply, creating opportunities for emission reduction.

Purpose of the Study:

  • To document and analyze the strategies employed by four Melbourne hospitals to decrease N2O emissions.
  • To highlight the diverse clinical contexts and challenges encountered in reducing anesthetic gas-related greenhouse gas emissions.

Main Methods:

  • Case study analysis of four hospitals implementing N2O emission reduction strategies.
  • Two hospitals decommissioned reticulated N2O systems, transitioning to cylinder supplies based on clinical consultation and interdisciplinary collaboration.
  • Two hospitals with high N2O demand and shared infrastructure are conducting audits and trials to inform changes.

Main Results:

  • Successful decommissioning of reticulated N2O systems in two hospitals, demonstrating a viable pathway to emission reduction.
  • Ongoing efforts in two other hospitals facing challenges with high clinical demand and complex infrastructure.
  • Case studies illustrate varied approaches and obstacles in mitigating N2O emissions.

Conclusions:

  • Hospitals can effectively reduce nitrous oxide emissions through strategic changes in anesthetic gas supply.
  • Interdisciplinary collaboration and clinical consultation are crucial for successful transitions away from reticulated N2O systems.
  • Diverse strategies are necessary to address the varied clinical demands and infrastructural complexities in emission reduction efforts.