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Related Concept Videos

Gallbladder01:17

Gallbladder

The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins the common...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Related Experiment Video

Updated: Jul 7, 2026

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma
05:22

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Published on: February 13, 2026

Primary gallbladder melanoma - a rare entity or a diagnostic pitfall?

Radu Gheorghe Dan1, Gabriel Veniamin Cozma, Adrian Iosif Moldoveanu

  • 1Department of Surgery I, Victor Babeş University of Medicine and Pharmacy, Timişoara, Romania; adrian.moldoveanu@umft.ro.

Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie
|July 6, 2026
PubMed
Summary

Primary gastrointestinal (GI) melanoma is rare and debated. Most GI melanomas are metastatic, but distinguishing primary lesions requires careful evaluation to exclude occult or regressed cutaneous melanoma.

Keywords:
gastrointestinal melanomametastatic melanomaprimary gallbladder melanomaspontaneous regression

Related Experiment Videos

Last Updated: Jul 7, 2026

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma
05:22

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Published on: February 13, 2026

Area of Science:

  • Gastroenterology
  • Oncology
  • Dermatology

Background:

  • Primary gastrointestinal (GI) melanoma is a rare and controversial diagnosis.
  • Most GI melanomas are considered metastatic from cutaneous melanoma, but primary origin is debated.
  • Diagnosis is complicated by occult, amelanotic, or regressed primary cutaneous melanomas.

Purpose of the Study:

  • To review literature on GI and gallbladder melanoma.
  • To differentiate primary versus metastatic lesions.
  • To analyze recent cases of GI and gallbladder melanoma.

Main Methods:

  • Literature review of GI and gallbladder melanoma.
  • Analysis of three departmental cases diagnosed within five years.
  • Clinicopathological evaluation.

Main Results:

  • Three cases identified: one gallbladder melanoma, two small bowel melanomas.
  • Cases presented diverse clinical scenarios including GI bleeding and amelanotic melanoma.
  • Findings highlight diagnostic challenges in differentiating primary GI melanoma.

Conclusions:

  • Cautious interpretation is crucial when diagnosing primary GI melanoma.
  • Metastatic disease from occult or regressed cutaneous melanoma must be excluded.
  • Multidisciplinary clinicopathological evaluation is essential.