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Updated: Jul 7, 2026

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance

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The Relation Between Antibiotic Use and Gastrointestinal Cancer: A Systematic Review and Meta-Analysis.

Yiwei Wang¹, Shining Jin¹, Longfei Xu¹

¹Department of Anorectum, The Affiliated Hospital of Changchun University of Chinese Medicine, China.

Journal of Biochemical and Molecular Toxicology

|July 6, 2026

Summary

Antibiotic use is linked to an increased risk of gastrointestinal (GI) cancers, including colorectal cancer (CRC). This risk appears to increase with more frequent or prolonged antibiotic exposure, highlighting the need for judicious prescribing.

Keywords:

antibiotic use gastrointestinal cancer meta‐analysis

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Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance

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Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Published on: November 17, 2018

Area of Science:

Oncology
Microbiology
Public Health

Background:

Cancer is a leading cause of global mortality, with rising incidence rates.
Antibiotic use is a potential risk factor for certain cancers, particularly colorectal cancer (CRC), possibly due to microbiome disruption.
Existing evidence is inconsistent, necessitating a comprehensive synthesis.

Purpose of the Study:

To systematically review and meta-analyze the association between antibiotic use and gastrointestinal (GI) cancer risk.
To investigate dose-response relationships and identify potential biological mechanisms.

Main Methods:

Systematic retrieval of studies from major databases (PubMed, Web of Science, Scopus, Embase).
Inclusion of 12 studies in a meta-analysis using a random-effects model.
Assessment of publication bias and heterogeneity; analysis of odds ratios (OR) and confidence intervals (CI).

Main Results:

Antibiotic use was associated with an 18.7% increased risk of GI cancers (OR=1.187).
A significant association was found with CRC risk (OR=1.208).
Dose-response relationships were observed for prescription frequency and duration, indicating higher risk with increased exposure.

Conclusions:

A modest but statistically significant association exists between antibiotic use and increased GI cancer risk.
The findings suggest potential mechanisms involving microbiome alteration, inflammation, and immune function.
Judicious antibiotic prescribing is crucial given the global impact of widespread use.