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Related Experiment Video

Updated: Jul 7, 2026

Nerve-sparing Mid-urethral Obstruction (NeMO) in Female Small Rodents
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Microablative Radiofrequency Versus Sham for Overactive Bladder: A Randomized Controlled Trial With 6 Months Follow

Constanza Alvear1, Cássia Raquel Teatin Juliato2, Anna Lygia B Lunardi1

  • 1Department of Surgery, School of Medical Sciences, Postgraduate Program in Surgery Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.

Neurourology and Urodynamics
|July 6, 2026
PubMed
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Stress Urinary Incontinence Treatment With Microablative Radiofrequency, Pelvic Floor Muscle Training or Combination of Both Techniques in Climacteric Women: Randomized Controlled Trial 6-Month Follow-Up.

Neurourology and urodynamics·2025

Radiofrequency (RF) treatment combined with behavioral therapy (BT) improved overactive bladder (OAB) symptoms in women, with effects lasting six months. However, RF did not show superiority compared to sham treatment, highlighting BT as a key therapy for OAB.

Area of Science:

  • Urology
  • Gynecology
  • Medical Devices

Background:

  • Overactive bladder (OAB) is a common condition affecting women.
  • Energy-based treatments like radiofrequency (RF) show potential for urinary incontinence.
  • Evidence for RF in treating OAB specifically is limited.

Purpose of the Study:

  • To evaluate the efficacy of microablative RF compared to sham treatment in women diagnosed with OAB.
  • To assess the long-term effects of RF treatment over a 6-month follow-up period.

Main Methods:

  • A bicenter, randomized, double-blind, parallel-group trial was conducted.
  • 140 women aged 45-65 with OAB were randomized to receive either RF or sham treatment, alongside behavioral therapy (BT).
  • Assessments included validated questionnaires, bladder diaries, and pelvic floor evaluations.
Keywords:
follow‐up studiesoveractive bladderplacebosradiofrequencyrandomized controlled trial

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Main Results:

  • Both RF and sham groups demonstrated significant improvements in OAB symptoms, sustained at 6 months.
  • The RF group showed improvements in pelvic floor tone and reduced pain, but also reported more adverse events.
  • No statistically significant superiority of RF over sham treatment was found for the primary outcome.

Conclusions:

  • Microablative RF combined with BT effectively improves OAB symptoms with sustained effects.
  • The study did not find RF to be superior to sham treatment when added to BT.
  • Behavioral therapy remains a valuable first-line treatment recommendation for OAB.