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Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
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Psychiatric Risk in Chronic Spontaneous Urticaria: A Retrospective Cohort Study.

Philip Curman1, Henning Olbrich2, Khalaf Kridin3

  • 1Dermato-Venereology Clinic, Karolinska University Hospital, Stockholm, Sweden; Dermatology and Venereology Division, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

Acta Dermato-Venereologica
|July 6, 2026
PubMed
Summary

Chronic spontaneous urticaria (CSU) is linked to a small increase in stress-related disorders, but not broadly to other psychiatric conditions like depression or schizophrenia. This study clarifies the specific mental health risks associated with CSU.

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Area of Science:

  • Dermatology
  • Psychiatry
  • Epidemiology

Background:

  • Chronic spontaneous urticaria (CSU) is frequently linked to psychiatric conditions.
  • Previous research is limited by study design, potentially causing bias and reverse causation.

Purpose of the Study:

  • To investigate the risk of new psychiatric disorders following a CSU diagnosis.
  • To differentiate specific psychiatric morbidities associated with CSU.

Main Methods:

  • Retrospective matched cohort study using the TriNetX US Collaborative Network.
  • Propensity score matching (1:1) of adults with new CSU diagnoses to controls without CSU.
  • 3-year follow-up for incident depression, stress/adjustment disorders, schizophrenia, and suicide-related outcomes.

Main Results:

  • CSU was associated with a modest increase in stress-related disorders (HR 1.15, 95% CI 1.09-1.22).
  • No consistent increased risk was found for depression, schizophrenia, or suicide-related outcomes.
  • Sensitivity analyses confirmed the association with stress-related disorders.

Conclusions:

  • CSU is not broadly associated with incident psychiatric disease.
  • A small, reproducible increase in stress-related psychiatric morbidity is linked to CSU.
  • Findings suggest a specific link rather than generalized psychiatric comorbidity.