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Rationale and design of Dongzong CArdIovascuLar Bio-imaging RegistrY (DAILY) study: Bridging multiomics, imaging and
Junqing Ma1, Baosen Zhu1, Junhao Li2
1Department of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, China.
Insights
The Dongzong Cardiovascular Bio-imaging Registry (DAILY) study is building a large Chinese bioimaging database to understand cardiovascular disease (CVD) better. It investigates genetic and environmental factors influencing CVD and its intermediate phenotypes.
Area of Science:
- Cardiology
- Genetics
- Medical Imaging
Background:
- Cardiovascular disease (CVD) is a leading global cause of mortality.
- Personalized precision medicine requires large-scale bioimaging databases.
- Ethnic disparities exist in CVD genetics and imaging.
Purpose of the Study:
- Establish a large-scale Chinese cardiovascular bioimaging database (Dongzong Cardiovascular Bio-imaging Registry - DAILY study).
- Address ethnic disparities in genetics and imaging for CVD.
- Elucidate mechanisms of genetic and exposure factors on imaging-derived phenotypes and CVD.
Main Methods:
- Prospective, multicenter study enrolling 50,000 adults across China.
- Collects data on exposure factors, multiomics (blood, saliva), and cardiopulmonary CT imaging.
- Primary outcome: composite major adverse cardiovascular event (MACE).
Main Results:
- Recruited 8699 participants in Nanjing, China, by September 10, 2025.
- Collected biospecimens (blood, saliva) and completed cardiopulmonary CT scans for most participants.
- Achieved a 98.9% 1-year follow-up rate.
Conclusions:
- Deepen understanding of ethnic disparities in CVD.
- Elucidate effects of genetic and exposure factors on cardiopulmonary phenotypes.
- Decipher pathophysiological mechanisms underlying CVD.
Background:
Cardiovascular disease (CVD) remains the leading cause of global mortality, necessitating a large-scale bioimaging database to advance personalized precision medicine strategies.
Objectives:
The Dongzong Cardiovascular Bio-imaging Registry (DAILY) study was designed to establish a large-scale Chinese cardiovascular bioimaging database (NCT06894095). It aims to address ethnic disparities in genetics and imaging, and to elucidate crucial driving mechanisms and effects of genetic biology and exposure factors on imaging-derived intermediate phenotypes and CVD.
Methods:
This prospective, multicenter study plans to enroll 50,000 adults from six medical centers across China. It employs a comprehensive data framework, systematically collecting information on exposure factors, high-throughput multiomics (blood and saliva samples), and cardiopulmonary computed tomography (CT) imaging (chest CT, cardiac CT) for cardiac, coronary and pulmonary phenotypes assessment. The primary outcome is a composite major adverse cardiovascular event, including all-cause death, nonfatal myocardial infarction, and nonfatal stroke.
Results:
To September 10, 2025, the study has recruited 8699 participants in Nanjing, China. Standardized biospecimen collection was performed, obtaining blood samples from 8632 participants and saliva specimens from 8621 individuals, and cardiopulmonary CT scans have been completed in 8699 participants. The cohort maintains a 1-year follow-up rate of 98.9%.
Conclusions:
The DAILY study will deepen our understanding of ethnic disparities in CVD, help elucidate the effects of genetic and exposure factors on cardiopulmonary intermediate phenotypes, and decipher the pathophysiological mechanisms underlying CVD.
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