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Related Concept Videos

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Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Encephalitis l: Introduction

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Related Experiment Video

Updated: Jul 7, 2026

Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes
08:56

Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes

Published on: October 10, 2025

Kikuchi-Fujimoto Disease Presenting With Complex Neurological Manifestations: A Case Report.

Yusuf Kagzi1, Suban Amatya2, Ashutosh Gupta3

  • 1Department of Internal Medicine, University of Illinois College of Medicine, Peoria, Illinois, USA, uic.edu.

Case Reports in Neurological Medicine
|July 6, 2026
PubMed
Summary

Kikuchi-Fujimoto Disease (KFD) can rarely affect the central nervous system. This case shows rituximab effectively treated a patient with progressive KFD neurological symptoms, likely due to vasculitis.

Keywords:
Kikuchi diseaseneuropathyvasculitis

Related Experiment Videos

Last Updated: Jul 7, 2026

Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes
08:56

Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes

Published on: October 10, 2025

Area of Science:

  • Neurology
  • Immunology
  • Pathology

Background:

  • Kikuchi-Fujimoto Disease (KFD) is a rare inflammatory disorder.
  • Central nervous system (CNS) involvement in KFD is exceptionally uncommon.
  • Previous KFD diagnosis in the patient resolved with steroids.

Purpose of the Study:

  • To describe an atypical, progressive CNS presentation of KFD.
  • To highlight diagnostic challenges in rare neurological manifestations of KFD.
  • To evaluate the efficacy of rituximab in refractory KFD CNS involvement.

Main Methods:

  • Case report of a 43-year-old male with progressive neurological deficits.
  • Review of patient's medical history, including prior KFD diagnosis.
  • Diagnostic workup to exclude other conditions.
  • Treatment with rituximab for CNS involvement.

Main Results:

  • The patient presented with severe, progressive neurological symptoms including gait imbalance, dysarthria, and hypersomnolence.
  • Diagnosis of CNS involvement secondary to KFD, likely vasculitis-mediated, was established.
  • Rituximab treatment led to significant symptom improvement.

Conclusions:

  • This case underscores the importance of considering rare neurological presentations of KFD.
  • Atypical KFD with extensive CNS involvement may involve vasculitis.
  • Rituximab can be effective in managing refractory KFD CNS disease.