Influence of Preconception Maternal BMI and Gestational Weight Gain on Perinatal Outcomes

Sunita Palo1, Sabina Terzic1

  • 1Neonatal Intensive Care Unit, Clinical Center University of Sarajevo, Sarajevo, BIH.

Cureus
|July 6, 2026
PubMed

Introduction Inadequate BMI in women before conception, as well as non-optimal gestational weight gain (GWG) during pregnancy, affects the health of the mother and newborn. The aim of this study was to examine the influence of maternal BMI before conception and GWG during pregnancy on perinatal outcomes in newborns and mothers. Methods A retrospective study was conducted at the Clinic for Gynecology and Obstetrics and the Pediatric Clinic, Clinical Center University of Sarajevo (CCUS), from January 1, 2024 to December 31, 2024. A total of 2,067 participants were included in the study. Descriptive statistical methods were used. The analyzed perinatal outcomes included method of conception, type of delivery, birth weight of newborns, Apgar score at 1 minute, need for NICU hospitalization, and development of disease or other complications related to maternal health. Results The majority of the participants, 60.9% (n = 1,259), had a normal BMI, 27.1% (n = 559) were overweight, 9.1% (n = 189) were obese, and 2.9% (n = 60) were underweight. The average GWG was 15.1 kg; 46.0% (n = 952) of the subjects had excessive GWG, 37.4% (n = 772) had GWG within the recommended range, and 16.6% (n = 343) had low GWG. A statistically significant association was found between maternal BMI and mode of conception, type of delivery, prematurity, birth weight, Apgar score, need for NICU hospitalization, and presence of maternal diseases. GWG was significantly associated with infant birth weight, Apgar score, and the presence of maternal diseases. Conclusion The conducted study provides data on the significant and non-negligible association of inadequate maternal BMI before pregnancy and non-optimal GWG during pregnancy with adverse perinatal outcomes. Education and preventive promotion of body weight control must become a priority in public health among women and future mothers to reduce the risk of less favorable perinatal outcomes for the mother and newborn.

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Regression Toward the Mean01:52

Regression Toward the Mean

Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when researchers try to extrapolate results...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...