Concomitant Cervicofacial Squamous Cell Carcinoma and Hepatocellular Carcinoma: A Rare Cadaveric Case Report

Multiple primary malignancies are uncommon, with the coexistence of cervicofacial squamous cell carcinoma (SCC) and hepatocellular carcinoma (HCC) being exceptionally rare. To our knowledge, very few cases describing concurrent SCC and HCC have been reported. This report describes the incidental cadaveric discovery of advanced SCC and HCC in the same individual and correlates gross anatomical findings with histopathologic evaluation. During a routine cadaveric dissection at William Carey University College of Osteopathic Medicine, a 64-year-old male cadaver was found to have extensive pathological changes involving the head and neck region and liver. Examination revealed prior mandibular resection with fixation hardware, tracheostomy placement, dense cervical fibrosis, and enlarged bilateral deep cervical lymph nodes. Histopathologic evaluation of cervical soft tissue demonstrated invasive SCC with infiltration through multiple tissue layers. Abdominal dissection revealed a markedly enlarged cirrhotic liver containing numerous nodules ranging from 0.5 to 5 cm, including a large caudate lobe mass compressing the portal triad. Histopathologic analysis confirmed multifocal HCC with portal vein invasion superimposed on advanced cirrhosis. This case highlights the rare synchronous occurrence of SCC and HCC identified incidentally during cadaveric dissection. It underscores the importance of thorough histopathologic evaluation in distinguishing multiple primary malignancies from metastatic disease and demonstrates the educational value of cadaveric dissection in correlating gross pathology with advanced malignancy.