Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular tachycardia.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proposed Classification System for the 445 nm Blue Light Laser for Treatment of Laryngeal Lesions.

Journal of voice : official journal of the Voice Foundation·2026
Same author

Staged "Top-Up" Injection Laryngoplasty for Large Glottic Gaps in Unilateral Vocal Fold Paralysis.

The Laryngoscope·2026
Same author

Evaluating Appropriateness of Interfacility Transfers for Patients with Facial Trauma Including Acute Orbital Floor Fractures.

Facial plastic surgery & aesthetic medicine·2026
Same author

Diagnostic and Therapeutic Strategies for Brain Metastases from Unknown Primary Tumors: A Comprehensive Review.

Journal of clinical medicine·2026
Same author

Assessing the Area Deprivation Index in Relation to Orbital Floor Fractures.

The Laryngoscope·2026
Same author

Safety and Feasibility of Transcatheter Aortic Valve Replacement in Patients With Hematologic Neoplasms.

JACC. Case reports·2026

Related Experiment Video

Updated: Jul 7, 2026

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

Radiation-associated bioprosthetic valve dysfunction: an initial case-control analysis.

Ioana Petrescu1, Atif M Islam2, Brian Blair3

  • 1Department of Cardiology, West Virginia University, Morgantown, WV, United States.

Frontiers in Cardiovascular Medicine
|July 6, 2026
PubMed
Summary

Radiation therapy (RT) for intrathoracic malignancies can increase transvalvular gradients in bioprosthetic heart valves. These dose-dependent changes necessitate long-term monitoring of valve function after chest RT.

Keywords:
bioprosthetic valvecardiotoxicityhemodynamicsradiation-associated heart diseaseradiotherapytransvalvular gradientvalve durabilityvalvular heart disease

More Related Videos

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
04:30

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

Related Experiment Videos

Last Updated: Jul 7, 2026

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
04:30

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

Area of Science:

  • Cardiology
  • Oncology
  • Radiology

Background:

  • Radiation therapy (RT) for intrathoracic and breast cancers is linked to valvular heart disease (VHD) in native valves.
  • The impact of RT on bioprosthetic heart valves (BHVs) is not well understood.

Purpose of the Study:

  • To evaluate changes in transvalvular gradients in patients with BHVs after receiving chest RT.
  • To determine the relationship between RT dose and gradient changes in BHVs.

Main Methods:

  • A retrospective study comparing 23 patients who received BHV implantation followed by chest RT with matched controls.
  • Serial echocardiographic gradients were analyzed at multiple time points post-implantation and post-RT.
  • Univariable linear regression assessed the association between RT dose metrics, timing, and gradient changes.

Main Results:

  • Transvalvular gradients significantly increased over time in the RT group, unlike in controls.
  • Both total RT dose and mean heart RT dose correlated with increased gradients within 12 and 12-24 months post-RT.
  • Shorter intervals between BHV implantation and RT predicted greater gradient increases; no re-interventions were needed.

Conclusions:

  • Chest RT is associated with early, dose-dependent increases in transvalvular gradients in BHVs.
  • Observed gradient changes were modest, not requiring re-intervention during the follow-up period.
  • Long-term surveillance is crucial for assessing the durability of irradiated BHVs.