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Published on: October 26, 2017
Circulating miR-107, miR-199, and miR-485 Have High Diagnostic Potential in Non-small Cell Lung Cancer: An
Murat Serilmez1, Sena Sen1, Emre Ozgur1
1Department of Basic Oncology, Oncology Institute, Istanbul University, Topkapi Neighborhood, Millet Street, Fatih, Istanbul, Turkey.
Clinical Medicine Insights. Oncology
|July 6, 2026
Summary
Circulating microRNAs (miRNAs) like miR-107, miR-199, and miR-485 show potential as non-invasive biomarkers for non-small cell lung cancer (NSCLC). These specific miRNAs were found at lower levels in NSCLC patients, aiding in diagnosis.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Non-small cell lung cancer (NSCLC) represents the majority of lung cancer diagnoses.
- Circulating microRNAs (miRNAs) are emerging as promising non-invasive biomarkers for cancer detection.
- This study explores the diagnostic and prognostic value of four specific circulating miRNAs in NSCLC.
Purpose of the Study:
- To investigate the diagnostic potential of miR-107, miR-199-3p, miR-485-5p, and miR-574-5p in non-small cell lung cancer (NSCLC).
- To assess the prognostic value of these circulating miRNAs in NSCLC patients.
- To identify novel non-invasive biomarkers for NSCLC detection and patient stratification.
Main Methods:
- Serum samples were collected from 58 NSCLC patients and 20 healthy controls.
- Quantitative RT-PCR was used to measure the relative expression levels of four target miRNAs.
- Statistical analyses included Mann-Whitney U test, ROC curve analysis, and univariate/multivariate regression.
Main Results:
- miR-107, miR-199, and miR-485 were significantly downregulated in NSCLC patients compared to controls (p < 0.001, p < 0.001, p = 0.002).
- miR-574 expression did not differ significantly between groups (p = 0.370).
- ROC analysis showed significant discriminatory power for all four miRNAs, with miR-107 having the highest AUC (0.952). ECOG performance status and miR-199 were significant prognostic factors.
Conclusions:
- Circulating miR-107, miR-199, and miR-485 demonstrate significant potential as discriminative biomarkers for NSCLC.
- These miRNAs could serve as valuable non-invasive markers for NSCLC diagnosis.
- Further validation in larger cohorts is warranted to confirm their clinical utility.
