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Updated: Jul 7, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Synthesis and structure of norfloxacinium acetate sesquihydrate
Abdusamat Rasulov1, Batirbay Torambetov2, Aziza Erejepova2
1Termez University of Economics and Service, 41B Farovon St, Termiz, 190111, Uzbekistan.
Abstract:
The title hydrated salt, C16H19FN3O3 +·C2H3O2 -·1.5H2O, crystallizes with two cations, two anions and three water mol-ecules of crystallization in the asymmetric unit. The protonation of the piperazine secondary amine group of norfloxacin occurs via proton transfer from acetic acid. In the extended structure, the components are linked into chains propagating along the a-axis direction through numerous N-H⋯O and O-H⋯O hydrogen bonds. Hirshfeld surface analysis and two-dimensional fingerprint plots confirm the significant contribution of H⋯O inter-actions to the consolidation of the crystal structure.
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